Chinese scientists altered the genome of an adult using CRISPR technology

Chinese scientists for the first time in the world to conduct an experiment to edit the genome of an adult with the help of technology CRISPR/Cas9. 28 Oct patient with lung cancer has introduced a modified T-lymphocytes. On the experiment reported in editorial material Nature, writes N+1.

Trials metasteziruuschem patients with non-small cell lung cancer resistant to other treatments, introduce their own T-lymphocytes, which use technology called CRISPR/Cas9 has been deleted gene of the membrane protein PD-1. This protein suppresses cell-mediated immunity and allows the tumor to inactivate lymphocytes. Currently, to block this protein used drugs based on antibodies, but the response to them is very different in different patients. Scientists hope that the effect of the use of CRISPR is more pronounced and predictable.

Infusion of T-lymphocytes the first patient was successful, and soon he will introduce a second dose of modified cells. In the case of this first patient does not appear pronounced side effects, the number of subjects with metasteziruuschem non-small cell lung cancer will increase to 10.

System CRISPR/Cas9 were found in the genome of the bacteria, where it plays a role in antiviral protection. This system allows the directional edit the DNA of an organism without affecting other parts of the genome.

Potentially, the technology of CRISPR/Cas9 is able to change the attitude of humanity to hundreds and thousands of hereditary diseases. If earlier they were either fully reversible or admitted for palliative care, symptomatic treatment, now opens the possibility to treat them «for real», that is, to eliminate the cause of the disease.

We will remind, this year the Nobel prize in medicine was awarded to a Japanese biologist who managed to install samopoedaniya genes of human cells.




Chinese scientists altered the genome of an adult using CRISPR technology 17.11.2016

0
Ноябрь 17th, 2016 by
36 queries